Cases in Precision Oncology: Complex In-frame DELINS in Cancer
Cases in Precision Oncology: Complex In-frame DELINS in Cancer
Availability
On-Demand
Expires on Feb 03, 2027
Cost
$0.00
Credit Offered
1 CME (AMA) Credit
1 CME (Other) Credit

Date of Release: February 3, 2025

Expiration Date: February 3, 2027

Credits offered:

Estimate time of completion: 1 hour

Course must be completed by the expiration date

 

Cases in Precision Oncology: Complex In-frame DELINS in Cancer

 

Description

Complex In-frame Variants in Cancer: How to recognize and communicate these variants when your informatics pipeline does not

Dr. Kandelaria (Ande) Rumilla, Beth Pitel, and Kaitlyn Paxton are some of the technical experts that work behind the scenes at Mayo Clinic Genomic Technologies Laboratory, part of the Department of Laboratory Medicine and Pathology at Mayo Clinic, to investigate genomic and transcriptomic variants at a sequence level.  In this session, the team will highlight the importance of understanding the genomic frame status in solid tumor testing.

Target Audience

All medical and healthcare professionals and researchers interested in understanding cancer genomic testing and somatic and germline variant interpretation methods. This series is presented as a collaboration between ClinGen Somatic, VICC, and ACMG consortia.

Learning Objectives

At the conclusion of this session, participants should be able to:

 

  • List 3 genes that are known to have actionable in-frame mutations in cancer.
  • Describe how 2 frameshift mutations may or may not have an overall in-frame effect.
  • Explain how interpreting variants as in-frame or out-of-frame can alter patient management.
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Moderator:

Jason Saliba, PhD

Senior Scientist, Instructor

Washington University School of Medicine in St. Louis

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Presenters

Kandelaria (Ande) Rumilla, MD

Laboratory Director, Anatomic Pathology and Genomics

Division of Laboratory Genetics and Genomics, Department of Laboratory Medicine and Pathology

Assistant Professor of Laboratory Medicine and Pathology, Mayo Clinic

 

 

Beth Pitel, MS

Clinical Variant Scientist

Division of Laboratory Genetics and Genomics, Department of Laboratory Medicine and Pathology

Assistant Professor of Laboratory Medicine and Pathology, Mayo Clinic

 

Kaitlin Paxton

Technical Specialist, Mayo Clinic

Department of Laboratory Medicine and Pathology, Mayo Clinic



Planning Committee:
Beth Pitel, MS, CG(ASCP)
Gordana Raca, MD, PhD, FACMG
Manuela Benary, PhD
Jason Saliba, PhD
Jane Radford, MHA, CHCP
Claudia Barnett

CME AMA PRA Category 1 CreditTM

 

Accreditation

The American College of Medical Genetics and Genomics is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

 

Credit Designation

The American College of Medical Genetics and Genomics designates this enduring activity for a maximum of 1.0 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

 

The American Medical Association (AMA) defines physicians as those individuals who have obtained an MD, DO, or equivalent medical degree from another country. Non-physicians may request a certificate of attendance for their participation.

 

Claiming your Educational Credits

This activity consists of: View content, take a post-test, the test may be taken as often as necessary to achieve a passing score of 80% or better is required to receive credit.  If you do not achieve a passing score, the program will identify which questions you answered incorrectly so that you can review the module and try again. Complete the evaluation form.

 

Learner Data Consent

ACMG Education reports learner data to respective agency boards and you will be asked for consent during the evaluation process. Your compliance with deadlines and completing evaluations are part of the process in meeting learner needs and ACMG’s education mission.

 

Technical Support:
You can reach us by email at
education@acmg.net or call 301-718-9603.
Support Center Hours: Monday – Friday, 9:00 AM – 5:00 PM Eastern Time.

Accredited Continuing Education Financial Disclosure

The American College of Medical Genetics and Genomics (ACMG) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide Accredited Continuing Education (ACE) for physicians. ACMG is an organization committed to improvement of patient care and general health by the incorporation of genetics and genomics into clinical practice.

 

ACMG has implemented the following procedures to ensure the independence of ACE activities from commercial influence/promotional bias, the Accreditation Council for Continuing Medical Education (ACCME) requires that providers (ACMG) must be able to demonstrate that: 1) everyone in a position to control the content of an ACE activity has disclosed all financial relationships that they have had in the past 24 months with ineligible* companies; 2) ACMG has implemented a mechanism to mitigate relevant financial relationships; and 3) all relevant financial relationships with ineligible companies are disclosed to the learners before the beginning of the educational activity. The learners must also be informed if no relevant financial relationships exist.
*Ineligible companies are defined as those whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.

 

ACMG Education Policies

Please review the policies below regarding the ACMG Education program

 

All of the relevant financial relationships listed for these individuals have been mitigated.

Name

Role: Presenter/ Panelist / Moderator / Liaison / Planner / Peer Reviewer

Financial Disclosure for 24 Months (relationship is ongoing)

Claudia Barnett

Staff

Nothing to Disclose

Manuela Benary, PhD

Planner/Moderator

Speaker: Novartis

Gordana Raca, MD, PhD, FACMG

Planner

Nothing to Disclose

Jane Radford, MHA, CHCP

Staff

Nothing to Disclose

Beth Pitel, MS

Planner/ Presenter

Somatic Advisory Board: Qiagen

Jason Saliba, PhD

Planner

Nothing to Disclose

Kaitlin Paxton

Presenter

Nothing to Disclose

Kandelaria (Ande) Rumilla, MD

Presenter

Nothing to Disclose

Disclaimer

ACMG educational programs are designed primarily as an educational tool for health care providers who wish to increase their understanding of the application of genomic technologies to patient care. The ACMG does not endorse or recommend the use of this educational program to make patient diagnoses, particular by individuals not trained in medical genetics. Adherence to the information provided in these programs does not necessarily ensure a successful diagnostic outcome. The program should not be considered inclusive of all proper procedures and or exclusive of other procedures and that are reasonably directed at obtaining the same results. In determining the propriety of any specific procedure or, a healthcare provider should apply his or her own professional judgment to the specific clinical circumstances presented by the individual patient

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