June 24 - Cases in Precision Oncology: Complex In-frame DELINS in Cancer

Availability

Registration ends on June 24, 2025

Expires on Jul 24, 2025

Online Meeting

Jun 24, 2025 11:00 AM - 12:00 PM ET

Cost

$0.00

Credit Offered

1 CME (AMA) Credit

1 CME (Other) Credit

Cases in Precision Oncology: Complex In-frame DELINS in Cancer

Tuesday, June 24^th, 2025

11:00am-12:00pm ET

www.acmgeducation.net

Course Description

Complex In-frame Variants in Cancer: How to recognize and communicate these variants when your informatics pipeline does not

Dr. Kandelaria (Ande) Rumilla, Beth Pitel, and Kaitlyn Paxton are some of the technical experts that work behind the scenes at Mayo Clinic’s Genomic Technologies clinical laboratory to investigate genomic and transcriptomic variants at a sequence level. In this session, the team will highlight the importance of understanding the genomic frame status in solid tumor testing.

Target Audience

All medical and healthcare professionals and researchers interested in understanding cancer genomic testing and somatic and germline variant interpretation methods. This series is presented as a collaboration between ClinGen Somatic, VICC, and ACMG consortia.

Agenda

Presentations followed by live Q&A.

Learning Objectives

At the conclusion of this session, participants should be able to:

List 3 genes that are known to have actionable in-frame mutations in cancer.
Describe how 2 frameshift mutations may or may not have an overall in-frame effect.
Explain how interpreting variants as in-frame or out-of-frame can alter patient management.

	Moderator: Jason Saliba, PhD Senior Scientist, Instructor Washington University School of Medicine in St. Louis
	Presenters Kandelaria (Ande) Rumilla, MD Laboratory Director, Anatomic Pathology and Genomics Division of Laboratory Genetics and Genomics, Department of Laboratory Medicine and Pathology Assistant Professor of Laboratory Medicine and Pathology, Mayo Clinic
	Beth Pitel, MS Clinical Variant Scientist Division of Laboratory Genetics and Genomics, Department of Laboratory Medicine and Pathology Assistant Professor of Laboratory Medicine and Pathology, Mayo Clinic
	Kaitlin Paxton Technical Specialist, Mayo Clinic Department of Laboratory Medicine and Pathology, Mayo Clinic

Planning Committee:
Beth Pitel, MS, CG(ASCP)
Gordana Raca, MD, PhD, FACMG
Manuela Benary, PhD
Jason Saliba, PhD
Jane Radford, MHA, CHCP
Claudia Barnett

CME AMA PRA Category 1 CreditTM, & CME Other

Accreditation

The American College of Medical Genetics and Genomics is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit Designation

The American College of Medical Genetics and Genomics designates this live activity for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Claiming your Educational Credits

Complete the activity and carefully complete the evaluation form. The deadline to claim educational credits is within 30 days from the date of the activity. Educational credit requests after this date will not be accepted.

Learner Data Consent

ACMG Education reports learner data to respective agency boards and you will be asked for consent during the evaluation process. Your compliance with deadlines and completing evaluations are part of the process in meeting learner needs and ACMG’s education mission.

Technical Support:

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