June 24 - Cases in Precision Oncology: Complex In-frame DELINS in Cancer
(3)
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Availability
No future session
Expires on Jul 24, 2025
Cost
$0.00
Credit Offered
1 CME (AMA) Credit
1 CME (Other) Credit

 

Cases in Precision Oncology: Complex In-frame DELINS in Cancer

 

Tuesday, June 24th, 2025

11:00am-12:00pm ET

www.acmgeducation.net

 

Course Description

Complex In-frame Variants in Cancer: How to recognize and communicate these variants when your informatics pipeline does not

Dr. Kandelaria (Ande) Rumilla, Beth Pitel, and Kaitlyn Paxton are some of the technical experts that work behind the scenes at Mayo Clinic’s Genomic Technologies clinical laboratory to investigate genomic and transcriptomic variants at a sequence level.  In this session, the team will highlight the importance of understanding the genomic frame status in solid tumor testing.

Target Audience

All medical and healthcare professionals and researchers interested in understanding cancer genomic testing and somatic and germline variant interpretation methods. This series is presented as a collaboration between ClinGen Somatic, VICC, and ACMG consortia.

Agenda

Presentations followed by live Q&A. 

Learning Objectives

At the conclusion of this session, participants should be able to:

 

  1. List 3 genes that are known to have actionable in-frame mutations in cancer.
  2. Describe how 2 frameshift mutations may or may not have an overall in-frame effect.
  3. Explain how interpreting variants as in-frame or out-of-frame can alter patient management.
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Moderator:

Jason Saliba, PhD

Senior Scientist, Instructor

Washington University School of Medicine in St. Louis

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Presenters

Kandelaria (Ande) Rumilla, MD

Laboratory Director, Anatomic Pathology and Genomics

Division of Laboratory Genetics and Genomics, Department of Laboratory Medicine and Pathology

Assistant Professor of Laboratory Medicine and Pathology, Mayo Clinic

 

 

Beth Pitel, MS

Clinical Variant Scientist

Division of Laboratory Genetics and Genomics, Department of Laboratory Medicine and Pathology

Assistant Professor of Laboratory Medicine and Pathology, Mayo Clinic

 

Kaitlin Paxton

Technical Specialist, Mayo Clinic

Department of Laboratory Medicine and Pathology, Mayo Clinic



Planning Committee:
Beth Pitel, MS, CG(ASCP)
Gordana Raca, MD, PhD, FACMG
Manuela Benary, PhD
Jason Saliba, PhD
Jane Radford, MHA, CHCP
Claudia Barnett

CME AMA PRA Category 1 CreditTM, & CME Other

 Accreditation 

The American College of Medical Genetics and Genomics is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. 

Credit Designation 

The American College of Medical Genetics and Genomics designates this live activity for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. 

Claiming your Educational Credits 

Complete the activity and carefully complete the evaluation form. The deadline to claim educational credits is within 30 days from the date of the activity. Educational credit requests after this date will not be accepted. 

Learner Data Consent 

ACMG Education reports learner data to respective agency boards and you will be asked for consent during the evaluation process. Your compliance with deadlines and completing evaluations are part of the process in meeting learner needs and ACMG’s education mission.  

 Technical Support: 

You can reach us by email at education@acmg.net or call 301-718-9603. 

Support Center Hours: Monday – Friday, 9:00 AM – 5:00 PM Eastern Time. 

Accredited Continuing Education Financial Disclosure

The American College of Medical Genetics and Genomics (ACMG) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide Accredited Continuing Education (ACE) for physicians. ACMG is an organization committed to improvement of patient care and general health by the incorporation of genetics and genomics into clinical practice.

ACMG has implemented the following procedures to ensure the independence of ACE activities from commercial influence/promotional bias, the Accreditation Council for Continuing Medical Education (ACCME) requires that providers (ACMG) must be able to demonstrate that: 1) everyone in a position to control the content of an ACE activity has disclosed all financial relationships that they have had in the past 24 months with ineligible* companies; 2) ACMG has implemented a mechanism to mitigate relevant financial relationships; and 3) all relevant financial relationships with ineligible companies are disclosed to the learners before the beginning of the educational activity. The learners must also be informed if no relevant financial relationships exist.
*Ineligible companies are defined as those whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.

 

ACMG Education Policies

Please review the policies below regarding the ACMG Education program

 

All of the relevant financial relationships listed for these individuals have been mitigated.

Name

Role: Presenter/ Panelist / Moderator / Liaison / Planner / Peer Reviewer

Financial Disclosure for 24 Months (relationship is ongoing)

Claudia Barnett

Staff

Nothing to Disclose

Manuela Benary, PhD

Planner/Moderator

Speaker: Novartis

Gordana Raca, MD, PhD, FACMG

Planner

Nothing to Disclose

Jane Radford, MHA, CHCP

Staff

Nothing to Disclose

Beth Pitel, MS

Planner/ Presenter

Somatic Advisory Board: Qiagen

Jason Saliba, PhD

Planner

Nothing to Disclose

Kaitlin Paxton

Presenter

Nothing to Disclose

Kandelaria (Ande) Rumilla, MD

Presenter

Nothing to Disclose

Disclaimer

ACMG educational programs are designed primarily as an educational tool for healthcare professionals who wish to increase their understanding of the application of genomic technologies to patient care. The ACMG does not endorse, or recommend the use of this educational program to make patient diagnoses, particular by individuals not trained in medical genetics. Adherence to the information provided in these programs does not necessarily ensure a successful diagnostic outcome. The program should not be considered inclusive of all proper procedures and tests or exclusive of other procedures and tests that are reasonably directed at obtaining the same results. In determining the propriety of any specific procedure or test, a healthcare professional should apply his or her own professional judgment to the specific clinical circumstances presented by the individual patient or specimen.

Questions regarding CE credit should be directed to education@acmg.net

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