OasisLMS

Title: Overcoming Cytogenetic Diagnostic Challenges in Myeloid/Lymphoid Neoplasms with Eosinophilia and Tyrosine Kinase Fusions

Tuesday, September 23^rd, 2025

11:00am-12:00pm ET

www.acmgeducation.net

Course Description

This course reviews diagnostic challenges of FISH panels used to detect recurrent rearrangements in myeloid/lymphoid neoplasms with eosinophilia and tyrosine kinase fusions. We examine the cause and implications of false negative FISH results and discuss how complementary tests, such as chromosome analysis with metaphase FISH and RNA sequencing strategies, can help overcome these challenges. These cases highlight the importance of acknowledging the strengths and limitations of different assays to arrive at the correct diagnosis and guide patient management.

Target Audience

All health care professionals interested in the diagnosis and management of patients with hematologic malignancies. This series is presented as a collaboration between ClinGen Somatic, VICC, and ACMG consortia.

Agenda

Presentations followed by live Q&A. 

Learning Objectives

At the conclusion of this session, participants should be able to:

1. Compare and contrast strengths and limitations of chromosome analysis, interphase FISH, metaphase FISH, and RNA sequencing to detect chromosomal rearrangements.
2. Recognize the importance of pathology assessment and genetic testing in diagnosis of myeloid/lymphoid neoplasms with eosinophilia and tyrosine kinase gene fusions.
3. Explain the impact of making a specific diagnosis on patient management.

Moderator

Jason Saliba, PhD Instructor, Washington University School of Medicine

Presenters:

	Nathan Kopp, Ph.D., FACMG Assistant Professor of Pathology Medical College of Wisconsin Associate Director of Cytogenetics and Molecular Genomics Lab
	Ehab Atallah, MD Professor of Medicine Division of Hematology & Oncology Medical College of Wisconsin Associate Cancer Service Line Director
	Karen-Sue Carlson, MD, PhD Associate Professor of Medicine Division of Hematology & Oncology Medical College of Wisconsin
	Daniel Schlepphorst, DO Pediatric Hematology/Oncology/BMT Fellow Children’s Hospital of Wisconsin
	Maria Hintzke, MD Assistant Professor of Pathology Medical College of Wisconsin
	Eric Darrah, MD, PhD Hematopathology Fellow in Pathology Medical College of Wisconsin

Planning Committee:

Beth Pitel, MS, CG (ASCP)

Gordana Raca, MD, PhD, FACMG

Manuela Benary, PhD

Jason Saliba, PhD

Jane Radford, MHA, CHCP

Claudia Barnett 

AMA PRA Category 1 Credit^TM & CME Other)

Accreditation

The American College of Medical Genetics and Genomics is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit Designation
The American College of Medical Genetics and Genomics designates this live activity for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Claiming your Educational Credits

Complete the activity and carefully complete the evaluation form. The deadline to claim educational credits is within 30 days from the date of the activity. Educational credit requests after this date will not be accepted.

Learner Data Consent

ACMG Education reports learner data to respective agency boards and you will be asked for consent during the evaluation process. Your compliance with deadlines and completing evaluations are part of the process in meeting learner needs and ACMG’s education mission.

Technical Support:
You can reach us by email at education@acmg.net or call 301-718-9603.
Support Center Hours: Monday – Friday, 9:00 AM – 5:00 PM Eastern Time.