May 25, 2021- ClinGen Somatic Cancer and VICC Virtual Molecular Tumor Board Case Series- OnDemand
All medical and healthcare professionals and researchers interested in understanding cancer genomic testing and somatic and germline variant interpretation methods. This series is presented as a collaboration between ClinGen Somatic, VICC, and ACMG consortia.
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Expires on Jul 01, 2024
Credit Offered
1 CME (AMA) Credit
1 CME (Other) Credit
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May 25, 2021- ClinGen Somatic Cancer and VICC Virtual Molecular Tumor Board Case Series


Date of Release: July 28, 2021

Expiration Date: July 1, 2024

Credits offered: CME

Estimate time of completion: 1 hour

Course must be completed by the expiration date

Course Description

Identifying a wolf’s clothing – In this session, Drs. Nitya Patanjali and Laveniya Satgunaseelan present a case of an elderly male presenting with a large frontal lobe mass. Radiologically, the tumor showed no enhancement on imaging and was thought to be a low grade glioma. The subsequent histological findings and molecular profile did not accord with the clinical and radiological impression. We present an illustrative case of the implications of molecular profiling in CNS tumors, and its role in diagnosis, clinician-patient interaction and radiotherapy planning.

Each presentation in the case series will feature an oncologist and clinical laboratory scientist as speakers. The oncologist will present the clinical case vignette and the clinical laboratory scientist will present the genomic data and interpretation.

Target Audience

All medical and healthcare professionals and researchers interested in understanding cancer genomic testing and somatic and germline variant interpretation methods. This series is presented as a collaboration between ClinGen Somatic, VICC, and ACMG consortia.

Learning Objectives

At the conclusion of this session, participants should be able to:

  1. Identify the clinical guidelines, assays, and tools used to determine the correct interpretation for the cancer genome profile.
  2. Compare and contrast the findings from histology, radiology, and genomic testing.
  3. Discuss what led to the correct diagnosis in this patient.



Shruti Rao, M.S., MBA

Research Program Manager, Innovation Center for Biomedical Informatics

Research Instructor, Department of Oncology, Georgetown University Medical Center

Coordinator and Senior Biocurator, ClinGen Somatic Cancer Clinical Domain Working Group (CDWG)

Co-lead Variant Interpretation for Cancer Consortium Virtual Molecular Tumor Board (VICC-VMTB)



Laveniya Satgunaseelan, MBBS BMedSc FRCPA

Anatomical pathologist, Department of Neuropathology, Royal Prince Alfred Hospital

Dr. Laveniya Satgunaseelan received her medical degree from Monash University, Melbourne, Australia. She went on to complete her anatomical pathology training at Royal Prince Alfred Hospital and Douglass Hanly Moir Pathology, both in Sydney, with rotations in neuropathology and molecular pathology at RPAH. She is currently a staff specialist in the Department of Neuropathology, Royal Prince Alfred Hospital. Her main academic interests include the molecular classification of gliomas and cancer biology in the adolescent and young adult population, as well as medical student and resident education in neuropathology and molecular pathology. She is currently completing a PhD examining the genomic landscape of oral squamous cell carcinoma in young adults at the University of Sydney.

Nitya Patanjali, MD

Radiation Oncologist

Chris O’Brien Lifehouse, Royal Prince Alfred Hospital

Dr. Nitya Patanjali graduated with honors from Sydney University in 2000 and trained at Wollongong, St George and RPA hospitals. She undertook her Fellowship at the BC Cancer Agency in Vancouver, Canada in 2008, in the areas of prostate seed brachytherapy and CNS stereotactic radiosurgery. Her areas of interest include GU and CNS radiation oncology with sub-specialties including prostate brachytherapy and stereotactic radiosurgery. Current research endeavors include involvement in clinical trials in general CNS radiation oncology, spine radiosurgery and investigation of re-irradiation of high grade gliomas with fractionated stereotactic radiotherapy.

Continuing Education Information

CME, Educational Credits

The American College of Medical Genetics is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit Designation
The American College of Medical Genetics and Genomics designates this enduring activity for a maximum of 1.0 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Claiming your Educational Credits

Complete the activity, score 80% or better on the post-test, and carefully complete the evaluation form.

Financial Disclosures

Disclosure Statement

It is the policy of the American College of Medical Genetics and Genomics to plan and implement all of its educational activities in accordance with the ACCME Essentials and Areas and ACCME® Policies to ensure balance, independence, objectivity and scientific rigor. In accordance with the ACCME® Standards for Commercial Support, everyone (speakers, moderators, committee members and staff) who is in a position to control the content of an educational activity certified for AMA PRA Category 1 Credit™ is required to disclose all financial relationships with any commercial interests within the past 12 months that creates a real or apparent conflict of interest. Individuals who do not disclose will be disqualified from participating in a CME activity.

This disclosure pertains to relationships with ACCME-defined commercial interests whose products or services may be related to the subject matter of the presentation topic. Any real or apparent conflicts of interest related to the content of the presentations must be managed prior to the educational activity. ACMG will identify, review and resolve all conflicts of interests prior to an educational activity being delivered to learners.


  • ACMG will follow the ACCME’s expectation that no employees or owners of commercial interests will be involved as planners/faculty/presenters of a CME accredited activity.
  • The ACCME definition of a commercial interest is any entity producing, marketing, re-selling, or distributing health care goods or services consumed by, or used on, patients.
  • The ACCME does not consider providers of clinical service directly to patients to be commercial interests – unless the provider of clinical service is owned, or controlled by, an ACCME-defined commercial interest.
  • Diagnostic laboratories are not considered commercial interests unless they are owned by or have a sister organization which is a commercial interest.

Content Validation and Fair Balance

  1. ACMG follows the ACCME policy on Content Validation for CME activities, which requires:
  2. a) All recommendations involving clinical medicine must be based on evidence that is accepted within the profession of medicine as adequate justification for their indications and contraindications in the care of patients.
  3. b) All scientific research referred to, reported or used in CME in support or justification of patient care recommendations must conform to the generally accepted standards of experimental design, data collection and analysis.
  4. Activities that fall outside the definition of CME/CE; “Educational activities that serve to maintain, develop, or increase the knowledge, skills, and professional performance and relationships that a physician uses to provide services for patients, the public, or the profession” (source: ACCME and AMA) will not be certified for credit. CME activities that promote recommendations, treatment, or manners of practicing medicine or pharmacy that are not within the definition of CME/CE or, are known to have risks or dangers that outweigh the benefits or, are known to be ineffective in the treatment of patients.
  5. Presentations and CME/CE activity materials must give a balanced view of therapeutic options; use of generic names will contribute to this impartiality. If the CME/CE educational materials or content includes trade names, where available, trade names from several companies must be used.

Off-Label Uses of Products

When an off-label use of a product, or an investigational use not yet approved for any purpose, is discussed during an educational activity, the accredited sponsor shall require the speaker to disclose that the product is not labeled for the use under discussion, or that the product is still investigational. Discussions of such uses shall focus on those uses that have been subject of objective investigation.

HIPAA Compliance by Faculty

The ACMG supports medical information privacy. While the ACMG is not a “covered entity” under HIPAA 1996 and therefore is not required to meet these standards, ACMG wishes to take reasonable steps to ensure that the presentation of individually identifiable health information at ACMG-sponsored events has been properly authorized. All presenters have completed a form indicating whether they intend to present any form of individually identifiable healthcare information. If so, they were asked either to at that a HIPAA-compliant consent form is on file at their institution, or to send ACMG a copy of the HIPAA compliance form. This information is on record at the ACMG Administrative Office and will be made available upon request.


ACMG educational programs are designed primarily as an educational tool for health care providers who wish to increase their understanding of the application of genomic technologies to patient care. The ACMG does not endorse or recommend the use of this educational program to make patient diagnoses, particular by individuals not trained in medical genetics. Adherence to the information provided in these programs does not necessarily ensure a successful diagnostic outcome. The program should not be considered inclusive of all proper procedures and s or exclusive of other procedures and s that are reasonably directed at obtaining the same results. In determining the propriety of any specific procedure or, a healthcare provider should apply his or her own professional judgment to the specific clinical circumstances presented by the individual patient or specimen.

Questions regarding CE credit should be directed

Financial Disclosures

The following reported disclosures and none are relevant to the content of this course. All of the relevant financial relationships listed for these individuals have been mitigated.

Planning Committee and ACMG Staff*

The following have nothing to disclose.

Shruti Rao, MS, MBA (Planner, Moderator)

Beth Pitel, MS, CG(ASCP) (Planner)

Gordana Raca, MD, PhD, FACMG (Planner)


Alex Wagner, PhD (Planner)

Maximilian Muenke, MD, FACMG (ACMG CEO)

Jane Radford, MHA, CHCP (ACMG Director of Education)

Laveniya Satgunaseelan, MBBS BMedSc FRCPA (Presenter)

Nitya Patanjali, MD (Presenter)


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