Complementary Use of Circulating Tumor Cell Sequencing and Tumor Sequencing
Tuesday, March 25th, 202511:00am-12:00pm ETwww.acmgeducation.net
Course DescriptionDr. Kanwar will discuss a case where extensive molecular profiling was used to inform patient management in a solid tumor through both circulating tumor DNA (ctDNA) and solid tumor sequencing. This case will highlight some advantages to performing each of these testing modalities and the overall impact on patient care.
Target AudienceAll medical and healthcare professionals and researchers interested in understanding cancer genomic testing and somatic and germline variant interpretation methods. This series is presented as a collaboration between ClinGen Somatic, VICC, and ACMG consortia. AgendaPresentations followed by live Q&A. Learning ObjectivesAt the conclusion of this session, participants should be able to:
1. List the differences between sequencing ctDNA and solid tumor DNA.2. Explain why complementary ctDNA and solid tumor sequencing was helpful in this case.3. Describe a situation where ctDNA sequencing is preferred to solid tumor sequencing.
Moderator:Beth Pitel, MS
Clinical Variant Scientist, Mayo Clinic Assistant Professor, Department of Laboratory Medicine and Pathology, Mayo Clinic
Nisha Kanwar, PhDLaboratory Genetics and Genomics Fellow, Mayo ClinicDepartment of Laboratory Medicine and Pathology
CME AMA PRA Category 1 CreditTM, & CME Other
Accreditation
The American College of Medical Genetics and Genomics is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
Credit Designation
The American College of Medical Genetics and Genomics designates this live activity for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Claiming your Educational Credits
Complete the activity and carefully complete the evaluation form. The deadline to claim educational credits is within 30 days from the date of the activity. Educational credit requests after this date will not be accepted.
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Accredited Continuing Education Financial Disclosure
The American College of Medical Genetics and Genomics (ACMG) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide Accredited Continuing Education (ACE) for physicians. ACMG is an organization committed to improvement of patient care and general health by the incorporation of genetics and genomics into clinical practice.
ACMG has implemented the following procedures to ensure the independence of ACE activities from commercial influence/promotional bias, the Accreditation Council for Continuing Medical Education (ACCME) requires that providers (ACMG) must be able to demonstrate that: 1) everyone in a position to control the content of an ACE activity has disclosed all financial relationships that they have had in the past 24 months with ineligible* companies; 2) ACMG has implemented a mechanism to mitigate relevant financial relationships; and 3) all relevant financial relationships with ineligible companies are disclosed to the learners before the beginning of the educational activity. The learners must also be informed if no relevant financial relationships exist.*Ineligible companies are defined as those whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.
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All of the relevant financial relationships listed for these individuals have been mitigated.
NAME
ROLE
RELATIONSHIP/ COMPANY
Planning Member
Presenter Panelist Moderator
Peer Reviewer
Nisha Kanwar PhD
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Nothing to Disclose.
Beth Pitel, MS, CG(ASCP)
Advisory Board: Qiagen, LLC
Claudia Barnett
Gordana Raca, MD, PhD, FACMG
Jane Radford, MHA, CHCP
Jason Saliba, PhD
Manuela Benary, PhD
Speaker: Novartis
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