February 25 - Chromosomal Mimicry in Hematologic Malignancies
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Availability
Registration ends on February 25, 2025
Expires on Mar 25, 2025
Online Meeting
Feb 25, 2025 11:00 AM - 12:00 PM ET
Cost
$0.00
Credit Offered
1 CME (AMA) Credit
1 CME (Other) Credit

Chromosomal Mimicry in Hematologic Malignancies

Tuesday, February 25th, 2025
11:00am-12:00pm ET
www.acmgeducation.net

Course Description
Detection of structural variants (SVs) represents a critical component in the diagnostic evaluation and treatment of many hematologic malignancies. Whereas clinical SV testing mainly consists of traditional cytogenetic methodologies, technological innovations have led to alternative approaches with improved resolution. Using a plurality of molecular methodologies including targeted RNA-sequencing, Optical Genome Mapping (OGM) and Hi-C, we describe ‘chromosomal mimicry’ - a phenomenon in which chromosome morphology resembles a known SV but lacks the expected gene level rearrangement -  as an infrequent but recurrent finding with the potential to confound clinical management. Our study highlights the need for assays with gene-level resolution in the diagnostic evaluation of hematologic malignancies.

Target Audience
All medical and healthcare professionals and researchers interested in understanding cancer genomic testing and somatic and germline variant interpretation methods. This series is presented as a collaboration between ClinGen Somatic, VICC, and ACMG consortia. 

Agenda
Presentations followed by live Q&A.  

Learning Objectives
At the conclusion of this session, participants should be able to:

1.    Describe multiple methods of structural variant detection
2.    Define chromosomal mimicry
3.    Explain why molecular characterization is important for patient management


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Moderator:
Gordana Raca, MD, PhD, FACMG
Director, Clinical Cytogenomics Laboratory, Center for Personalized Medicine
Professor of Clinical Pathology, Keck School of Medicine of USC
Children’s Hospital of Los Angeles

 

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Adrian Dubuc, PhD, FACMG
Vice-Chair, Cytogenetics/Genomics Clinical Research
Director, Clinical Cytogenetics Laboratory 
Roswell Park Comprehensive Cancer Center

Valentina Nardi, MD
Associate Professor of Pathology – Massachusetts General Hospital

 

Amir T. Fathi, MD
Associate Professor of Medicine – Massachusetts General Hospital

Gabriela S. Hobbs, MD
Associate Professor of Medicine – Massachusetts General Hospital 

Scott T. Ryall, PhD
Associate Pathologist – Brigham and Women’s Hospital 
Instructor in Pathology – Harvard Medical School

Melissa M. Zhao, MD
Clinical Fellow in Pathology – Brigham and Women’s Hospital



Planning Committee:
Beth Pitel, MS, CG(ASCP)
Gordana Raca, MD, PhD, FACMG
Manuela Benary, PhD
Jason Saliba, PhD
Jane Radford, MHA, CHCP
Claudia Barnett  

CME AMA PRA Category 1 CreditTM, & CME Other

 Accreditation 

The American College of Medical Genetics and Genomics is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. 

Credit Designation 

The American College of Medical Genetics and Genomics designates this live activity for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. 

Claiming your Educational Credits 

Complete the activity and carefully complete the evaluation form. The deadline to claim educational credits is within 30 days from the date of the activity. Educational credit requests after this date will not be accepted. 

Learner Data Consent 

ACMG Education reports learner data to respective agency boards and you will be asked for consent during the evaluation process. Your compliance with deadlines and completing evaluations are part of the process in meeting learner needs and ACMG’s education mission.  

 Technical Support: 

You can reach us by email at education@acmg.net or call 301-718-9603. 

Support Center Hours: Monday – Friday, 9:00 AM – 5:00 PM Eastern Time. 

Accredited Continuing Education Financial Disclosure

The American College of Medical Genetics and Genomics (ACMG) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide Accredited Continuing Education (ACE) for physicians. ACMG is an organization committed to improvement of patient care and general health by the incorporation of genetics and genomics into clinical practice.

 

ACMG has implemented the following procedures to ensure the independence of ACE activities from commercial influence/promotional bias, the Accreditation Council for Continuing Medical Education (ACCME) requires that providers (ACMG) must be able to demonstrate that: 1) everyone in a position to control the content of an ACE activity has disclosed all financial relationships that they have had in the past 24 months with ineligible* companies; 2) ACMG has implemented a mechanism to mitigate relevant financial relationships; and 3) all relevant financial relationships with ineligible companies are disclosed to the learners before the beginning of the educational activity. The learners must also be informed if no relevant financial relationships exist.
*Ineligible companies are defined as those whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.

 

ACMG Education Policies

Please review the policies below regarding the ACMG Education program

 

All of the relevant financial relationships listed for these individuals have been mitigated.

 

NAME

ROLE

RELATIONSHIP/ COMPANY

 

Planning Member

Presenter Panelist Moderator

Peer Reviewer

 

Beth Pitel, MS, CG(ASCP)

 ● 

 

 

Advisory Board: Qiagen, LLC

Adrian Dubuc, PhD, FACMG 

 

  

 

 Nothing to Disclose.

Valentina Nardi, MD