OasisLMS

Title: Knowledgebase Resources Aiding the Assessment of the Clinical Impact of Somatic Variants Found in Cancer: In-Depth Looks at CIViC and OncoKB

Tuesday, August 26, 2025

11:00am-12:00pm ET

www.acmgeducation.net

Course Description

This course reviews CIViC and OncoKB, two prominent precision oncology knowledgebases available to the public, that contain clinical interpretations of somatic variants found in cancer. Tutorials on how to navigate each knowledgebase will be given along with details of how to use and apply the information to aid precision medicine.

Target Audience

All medical and healthcare professionals and researchers interested in understanding cancer genomic testing and somatic and germline variant interpretation methods. This series is presented as a collaboration between ClinGen Somatic, VICC, and ACMG consortia.

Agenda

Presentations followed by live Q&A. 

Learning Objectives

At the conclusion of this session, participants should be able to:

• Explain the precision oncology and cancer variant interpretation workflow.
• Describe the role of knowledge bases such as OncoKB and CIViC within the precision oncology/molecular pathology workflow.
• Identify the complexity involved in aggregating and standardizing variant annotations from distributed sources.
• Locate and evaluate clinical evidence related to a specific disease, gene, drug, or variant of interest.

Moderator:

Manuela Benary, PhD Bioinformatician Charité – Universitätsmedizin Berlin, Berlin, Germany

Presenters:

	Malachi Griffith, PhD Professor - Department of Medicine (Oncology) & Department of Genetics Assistant Director, The McDonnell Genome Institute Washington University School of Medicine - St. Louis, MO, USA
	Debyani Chakravarty, PhD Associate Member - Department of Pathology Lead Scientist OncoKB Memorial Sloan Kettering Cancer Center - New York, NY, USA

Planning Committee:

Beth Pitel, MS, CG (ASCP)

Gordana Raca, MD, PhD, FACMG

Manuela Benary, PhD

Jason Saliba, PhD

Jane Radford, MHA, CHCP

Claudia Barnett 

CME AMA PRA Category 1^TM

Accreditation

The American College of Medical Genetics and Genomics is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit Designation
The American College of Medical Genetics and Genomics designates this live activity for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Claiming your Educational Credits

Complete the activity and carefully complete the evaluation form. The deadline to claim educational credits is within 30 days from the date of the activity. Educational credit requests after this date will not be accepted.

Learner Data Consent

ACMG Education reports learner data to respective agency boards and you will be asked for consent during the evaluation process. Your compliance with deadlines and completing evaluations are part of the process in meeting learner needs and ACMG’s education mission.

Technical Support:
You can reach us by email at education@acmg.net or call 301-718-9603.
Support Center Hours: Monday – Friday, 9:00 AM – 5:00 PM Eastern Time.

Accredited Continuing Education Financial Disclosure

The American College of Medical Genetics and Genomics (ACMG) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide Accredited Continuing Education (ACE) for physicians. ACMG is an organization committed to improvement of patient care and general health by the incorporation of genetics and genomics into clinical practice.

ACMG has implemented the following procedures to ensure the independence of ACE activities from commercial influence/promotional bias, the Accreditation Council for Continuing Medical Education (ACCME) requires that providers (ACMG) must be able to demonstrate that: 1) everyone in a position to control the content of an ACE activity has disclosed all financial relationships that they have had in the past 24 months with ineligible* companies; 2) ACMG has implemented a mechanism to mitigate relevant financial relationships; and 3) all relevant financial relationships with ineligible companies are disclosed to the learners before the beginning of the educational activity. The learners must also be informed if no relevant financial relationships exist.
*Ineligible companies are defined as those whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.

ACMG Education Policies

Please review the policies below regarding the ACMG Education program

• Financial Disclosures and Mitigation Procedure
• ACMG Content Validation Policy
• ACMG Content Branding Policy

All of the relevant financial relationships listed for these individuals have been mitigated.

Disclaimer

ACMG educational programs are designed primarily as an educational tool for healthcare professionals who wish to increase their understanding of the application of genomic technologies to patient care. The ACMG does not endorse, or recommend the use of this educational program to make patient diagnoses, particular by individuals not trained in medical genetics. Adherence to the information provided in these programs does not necessarily ensure a successful diagnostic outcome. The program should not be considered inclusive of all proper procedures and tests or exclusive of other procedures and tests that are reasonably directed at obtaining the same results. In determining the propriety of any specific procedure or test, a healthcare professional should apply his or her own professional judgment to the specific clinical circumstances presented by the individual patient or specimen.

Questions regarding CE credit should be directed to education@acmg.net