September 28, 2021- ClinGen Somatic Cancer and VICC Virtual Molecular Tumor Board Case Series- OnDemand-September 28, 2021- ClinGen Somatic Cancer and VICC

Video Transcription

Video Summary

The video transcript is a presentation of a clinical case study involving comprehensive genomic profiling in a pediatric tumor. The presentation is part of the ClinGen Somatic Cancer in FDA Virtual Molecular Tumor Board series and features a group from Nationwide Children's Hospital. The case involved an adolescent female with a retroperitoneal tumor and hepatic metastatic disease. The presentation discusses the timeline of the patient's diagnosis and the results of the genomic testing. It includes information on the variant found in the tumor, the germline variant in the patient's DNA, and the somatic copy number alterations. The presentation also explores the implications of the findings for counseling and therapeutic strategies. It discusses the challenges of testing children for adult onset conditions and the decisions made by the family regarding testing the patient's sibling. The presentation concludes with a discussion on the benefits of combining clinical and translational studies in genomic profiling for pediatric tumors. The video does not specify any credits granted.

Keywords

clinical case study

genomic profiling

pediatric tumor

germline variant

somatic copy number alterations

counseling

therapeutic strategies

genomic testing

family decisions

pediatric tumors