September 27 - ClinGen Somatic Cancer and VICC Virtual Molecular Tumor Board Case Series - OnDemand-September 27, 2022- ClinGen Somatic Cancer and VICC

Video Transcription

Video Summary

The video transcript provided is a recording of a webinar titled "ClinGen Somatic Cancer and VICT Virtual Molecular Tumor Board Case Series" hosted by the ACMG Genetics Academy. The webinar focuses on therapy-related neoplasms, their diagnosis, and clinical perspective. The speakers include Dr. Yasmin Abaza, Dr. Juhua Gao, and Dr. Medina Sukunova from Northwestern University in Chicago. The webinar discusses the educational resource provided by the series and acknowledges the collaboration between various organizations and working groups involved in creating standards and guidelines for cancer variant interpretation. The webinar also provides details about the planning committee and the credits attendees can obtain by completing evaluations. The speakers present two cases related to therapy-related neoplasms, discussing their clinical and genetic aspects. They explain the challenges in treating these neoplasms due to organ dysfunction, comorbidities, and chemo-resistance. They highlight the poor outcomes associated with TP53 mutations and KMT2A rearrangements, and discuss the ongoing research efforts to develop targeted therapies for these high-risk subtypes. They also touch upon the role of germline variants and the importance of genetic counseling in the management of these patients. Overall, the webinar provides valuable insights into therapy-related neoplasms and highlights the need for further research and personalized treatment approaches.

Keywords

therapy-related neoplasms

diagnosis

clinical perspective

Northwestern University

cancer variant interpretation

chemo-resistance

targeted therapies

germline variants

genetic counseling

personalized treatment approaches