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The document outlines a list of questions related to the evaluation of cancer predisposition in patients. These questions focus on aspects such as reviewing the patient's personal and family history of cancer, clinical information suggestive of cancer predisposition, testing for cancer predisposition genes, and the presence of specific variants within a certain range. Furthermore, considerations are highlighted regarding the germline status of identified variants, including factors such as founder variants in cancer predisposition genes, the likelihood of germline variants in certain cancers, and the impact of family history on variant interpretation. The document underscores the importance of a comprehensive assessment when evaluating cancer predisposition in patients, taking into account various genetic and clinical factors to guide appropriate management and treatment decisions.
Keywords
cancer predisposition evaluation
personal history of cancer
family history of cancer
clinical information
cancer predisposition genes testing
specific variants
germline status
founder variants
genetic factors
clinical factors
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