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PPM - Germline Variant Reporting in Patients Under ...
Checklist
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The document is a checklist to be used during patient visits to ensure that certain criteria are being reviewed and recorded when reporting germline variants in patients undergoing tumor testing. The checklist includes questions regarding personal and family history of cancer, clinical information suggesting a cancer predisposition, inclusion of cancer-predisposition genes in testing, variant allele frequency, explanation for any deviations in VAF, known founder variants in genes associated with cancer predisposition syndrome, consideration of specific cancer types and their association with germline variants, consideration of family history of cancer, confirmation of presumed germline pathogenic variant through follow-up testing, consideration of clonal hematopoiesis of indeterminate potential, testing spectrum and limitations stated in the report, distinction between somatic and germline variation, and communication of somatic test results to the referring physician.
Keywords
patient visits
germline variants
tumor testing
checklist
cancer predisposition
variant allele frequency
founder variants
follow-up testing
clonal hematopoiesis
somatic test results
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