PPM -Counseling for Inherited Cancer Risk-Description and References

Description and References

Pdf Summary

This document describes counseling for individuals who are seeking evaluation for a potential inherited cancer risk based on personal or family history. Approximately 5-10% of cancer patients may have a genetic predisposition to cancer, especially breast, ovarian, colon, and uterine cancers. Genetic consultation can provide valuable information about the risk of developing cancer and the potential benefits of genetic testing. Patients with harmful mutations in known cancer syndrome genes may benefit from risk reduction strategies such as prophylactic surgery, chemoprevention, or increased cancer surveillance. Even when a mutation in a known cancer syndrome gene cannot be identified, individuals may still benefit from a cancer risk assessment to receive personalized screening recommendations. Relevant literature includes practice guidelines from the American College of Medical Genetics and Genomics and the National Society of Genetic Counselors for referral indications for cancer predisposition assessment, as well as clinical practice guidelines from the National Comprehensive Cancer Network (NCCN) for genetic/familial high-risk assessment for breast, ovarian, pancreatic, and colorectal cancers.

Keywords

inherited cancer risk

genetic predisposition

genetic consultation

harmful mutations

risk reduction strategies

cancer surveillance

mutation identification

cancer risk assessment

screening recommendations

genetic/familial high-risk assessment