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Catalog
PPM - Assessment for and Management of Lynch Syndr ...
Description and References
Description and References
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Pdf Summary
Lynch Syndrome, also known as hereditary non-polyposis colon cancer, is a hereditary cancer syndrome characterized by a significantly increased risk of colorectal and endometrial cancer, as well as several other types of cancer. This condition is caused by germline mutations in DNA mismatch repair genes. <br /><br />The main objectives in the assessment and management of Lynch Syndrome include the use of recommended diagnostic strategies to evaluate individuals suspected to have the condition and the implementation of appropriate surveillance and management if a mismatch repair mutation is identified. <br /><br />It is crucial to accurately assess and identify Lynch Syndrome in order to provide necessary cancer surveillance and risk reduction strategies. The most common mutations associated with Lynch Syndrome are MLH1 and MSH2, accounting for 70-90% of affected families, although mutations in MSH6, PMS2, and EPCAM genes are also possible. <br /><br />The available literature on Lynch Syndrome includes resources such as the National Comprehensive Cancer Network's guidelines on genetic/familial high-risk assessment for colorectal cancer, a comprehensive review on Lynch Syndrome in GeneReviews®, and a consensus statement by the US Multi-Society Task Force on Colorectal Cancer providing guidelines on genetic evaluation and management of the condition. <br /><br />In conclusion, Lynch Syndrome is a hereditary cancer syndrome with a heightened risk of various types of cancer. It is essential to accurately diagnose and manage the condition to provide appropriate surveillance and risk reduction strategies.
Keywords
Lynch Syndrome
hereditary non-polyposis colon cancer
colorectal cancer
endometrial cancer
germline mutations
DNA mismatch repair genes
diagnostic strategies
surveillance and management
genetic evaluation
cancer surveillance
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