PPM - Analysis of Acylcarnitines-Checklist

Checklist

Pdf Summary

This document serves as a checklist for healthcare professionals to ensure comprehensive and accurate acylcarnitine analysis in clinical settings, as of October 2024. It includes key steps and documentation requirements to be followed during patient visits for the analysis.<br /><br />1. **Review and Documentation**: Begin by reviewing the indication for testing and the patient's clinical history to ensure the necessity and context of the test.<br /><br />2. **Sample Handling**: Accurately document the sample derivatization and condition, along with the identity of the individual performing the assay, to maintain traceability and reliability.<br /><br />3. **Age-Appropriate References**: Utilize age-appropriate reference intervals to ensure the interpretability and relevance of results.<br /><br />4. **Quality Control Measures**: Incorporate both positive and negative quality control samples in each batch to verify accuracy. Additionally, include an internal standard mix sample and document quality control results meticulously.<br /><br />5. **Ratio and Reflex Testing**: Pay particular attention to relevant acylcarnitine ratios, especially when a low carnitine level is detected. Document any reflex testing performed to aid in comprehensive analysis.<br /><br />6. **Report Content**: The report should include concentrations of relevant acylcarnitine species and interpret the clinical significance of any abnormalities. Include differential diagnosis and recommendations for follow-up testing where applicable, to provide a complete clinical picture.<br /><br />By systematically addressing these points, clinicians can ensure that the acylcarnitine analysis is thorough, accurate, and clinically meaningful, aiding in better diagnosis and patient care outcomes.

Keywords

acylcarnitine analysis

healthcare checklist

clinical settings

sample handling

quality control

age-appropriate references

reflex testing

report content

patient care

diagnosis