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August 27 Evaluation Report
August 27 Evaluation Report
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The feedback reflects on a course examining the nuances of liquid biopsy detection of TP53 variants in pediatric oncology. Participants generally found the course informative and relevant, particularly in understanding cell-free DNA (cfDNA) and circulating tumor DNA (ctDNA), alongside challenges in distinguishing somatic versus germline TP53 variants. There was substantial interest in learning about mosaicism and clonal hematopoiesis. The course appears well-received, with a high score given for its educational clarity and organization.<br /><br />Participants appreciated discussions on liquid biopsy applications in pediatric cases, a field often dominated by adult oncology dialogues. Some respondents highlighted the need to better understand mosaic Li Fraumeni syndrome cases and suggested broader testing frameworks. The audience expressed interest in expanding topics to include artificial intelligence, minimal residual disease (MRD), somatic and germline testing overlaps, and methodologies like methylation and RNA sequencing.<br /><br />Despite its overall success, the course did encounter a few challenges. Some participants experienced difficulties with the enrollment process, and a portion of attendees found limited applicability to their specific practice, suggesting diverse participant backgrounds. Overall, the course was praised for its clarity, coherence, and impact on refining clinical and research approaches in genetic testing and variant interpretation. Suggestions for future topics in the program indicate a demand for both comprehensive subject coverage and more specialized domains.
Keywords
liquid biopsy
TP53 variants
pediatric oncology
cell-free DNA
circulating tumor DNA
mosaicism
clonal hematopoiesis
Li Fraumeni syndrome
artificial intelligence
genetic testing
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