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7. Heme II: Myeloid Neoplasms Ondemand
C07 Heme II Myeloid Neoplasms ADubuc
C07 Heme II Myeloid Neoplasms ADubuc
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Pdf Summary
This document provides an overview of myeloid neoplasms and cytogenetic findings. The author discusses different types of myeloid neoplasms, including Chronic Myelogenous Leukemia (CML), Polycythemia Vera (PV), Primary Myelofibrosis (MF), Essential Thrombocytopenia (ET), Myelodysplastic Syndromes (MDS), and Acute Myeloid Leukemia (AML). For each type, the author highlights key cytogenetic findings and associated clinical features.<br /><br />The author also discusses the importance of incorporating cytogenetic and molecular profiling into the diagnostic classification of hematologic malignancies. They emphasize the significance of cytogenetic driver events and numerical changes in AML diagnosis, as well as the use of cytogenetics in assessing prognosis.<br /><br />Furthermore, the document mentions specific cytogenetic findings and their implications. For example, -Y, +8, Trisomy 15, and -20q are considered age-related processes and not evidence of MDS in the absence of morphological criteria. The document also highlights the importance of identifying specific gene rearrangements, such as t(15;17) in Acute Promyelocytic Leukemia (APL) and inv(16)(p13q22) or t(16;16) in AML, as they have prognostic significance.<br /><br />In conclusion, the document underscores the role of cytogenetics in identifying molecular subgroups of myeloid diseases and distinguishing driver events from passenger events.
Keywords
myeloid neoplasms
cytogenetic findings
Chronic Myelogenous Leukemia
Polycythemia Vera
Primary Myelofibrosis
Essential Thrombocytopenia
Myelodysplastic Syndromes
Acute Myeloid Leukemia
hematologic malignancies
cytogenetic driver events
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