2023 ACMG Annual Clinical Genetics Meeting Digital Edition: Poster Gallery-The Youngest Son of Abraham Lincoln: A Possible Case of 22q11.2 Deletion Syndrome

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The document discusses the possibility that Thomas "Tad" Lincoln, the youngest son of Abraham Lincoln, had 22q11.2 deletion syndrome (22q11.2DS). This syndrome is a well-characterized condition that occurs in about 1 in 4000 live births. It is associated with facial features, heart anomalies, speech-language disorders, and neurocognitive impairments. The most common genetic cause is a deletion of a specific region on chromosome 22. <br /><br />Tad Lincoln exhibited several characteristics that are consistent with a possible diagnosis of 22q11.2DS. He had feeding problems, articulation disorders, and possible cleft palate. He also displayed impulsive and unrestrained behaviors, as well as difficulties with social interactions. Tad had trouble with education and it is unclear how far he progressed in his studies. He also had physical features such as a high forehead, hooded eyes, protuberant ears, and tapered fingers. <br /><br />Tad Lincoln died at the age of 18 from a cardiopulmonary problem, with symptoms of congestive heart failure. <br /><br />Based on historical documents, photographs, and contemporary reports, the authors hypothesize that Tad Lincoln had 22q11.2DS. They suggest that his health and behavioral issues could be attributed to this syndrome. However, it is important to note that there is no direct evidence or medical records to confirm this hypothesis. <br /><br />In conclusion, this document presents the case of Thomas "Tad" Lincoln as a possible example of 22q11.2 deletion syndrome. The authors highlight Tad's characteristics and behaviors that align with the syndrome, but further research and genetic testing would be needed to confirm this hypothesis.

Asset Subtitle

Presenting Author - Angela E. Scheuerle, MD, FAAP, FACMG; Co-Author - Cortney Vant Slot, SLP; Co-Author - Veronica Bordes Edgar, PhD;

Meta Tag

Phenotype

Intellectual disability

Dysmorphology

Congenital Anomaly

Cognitive Disorders

Clinical History

Chromosomal Abnormalities

Co-Author Veronica Bordes Edgar, PhD

Co-Author Cortney Vant Slot, SLP

Presenting Author Angela E. Scheuerle, MD, FAAP, FACMG

Keywords

Thomas Tad Lincoln

22q11.2 deletion syndrome

genetic disorder

facial features

heart anomalies

speech-language disorders

neurocognitive impairments

chromosome 22

feeding problems

impulsive behaviors