2023 ACMG Annual Clinical Genetics Meeting Digital Edition: Poster Gallery-The Expression Profile of ABCB11 Gene in Hepatocellular Carcinoma and Its Association with Clinical Outcomes

The Expression Profile of ABCB11 Gene in Hepatocellular Carcinoma and Its Association with Clinical Outcomes

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This document is a summary of a study conducted by Hubert Chen from Vanderbilt University that analyzes the expression and prognostic role of ABCB11 (BSEP) in hepatocellular carcinoma (HCC), which is the most common type of primary liver cancer. The study utilizes various open databases, including TCGA, UALCAN, GEPIA, OncoLnc, and cBioPortal.<br /><br />The findings of the study indicate that ABCB11 expression is significantly down-regulated in LIHC tumor tissues compared to normal tissues. The promoter methylation level of ABCB11 in LIHC is lower than that in normal liver tissue. Additionally, low expression of ABCB11 is correlated with shorter overall survival in LIHC patients.<br /><br />ABCB11 encodes BSEP, which is responsible for the secretion of bile acids into the bile canaliculus. The study also explores the correlation between ABCB11 expression and patient survival using Kaplan plots. It is suggested that ABCB11 may function as a potential tumor suppressor gene and its expression levels could serve as a prognostic predictive marker in LIHC patients.<br /><br />The study highlights the importance of understanding the expression and function of ABCB11 in hepatocellular carcinoma. The results provide valuable insights into the potential role of ABCB11 as a predictive marker for patient prognosis in LIHC.

Asset Subtitle

Presenting Author - Hubert Chen, BS;

Meta Tag

Bioinformatics

Databases

Genotype-Phenotype Correlations

Identification of Disease Genes

Presenting Author Hubert Chen, BS

Keywords

ABCB11

hepatocellular carcinoma

HCC

expression analysis

prognostic role

TCGA

patient prognosis

tumor suppressor gene

bile acids

Kaplan plots