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Catalog
2023 ACMG Annual Clinical Genetics Meeting Digital ...
Prenatal Genetic Screening and Diagnostic Testing ...
Prenatal Genetic Screening and Diagnostic Testing Before and After the Height of the Covid-19 Pandemic in The Bronx NY
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Pdf Summary
A recent study conducted at Montefiore Medical Center in the Bronx, NY examined the impact of the COVID-19 pandemic on prenatal genetic screening and diagnostic testing. The study found that the pandemic led to a decrease in prenatal genetic diagnostic procedures, such as amniocentesis and chorionic villus sampling (CVS), by 12.3%. However, there was a significant increase of 46.5% in prenatal cell-free DNA (cfDNA) screening rates during the pandemic.<br /><br />The researchers sought to determine if this trend continued in the two years following the height of the pandemic compared to the two years prior. The study analyzed data from patients seen at Montefiore Medical Center's Department of Obstetrics & Gynecology and Women's Health from November 2016 to July 2022. The data included the type of procedure, indication for procedure, and divided patients into pre-pandemic and post-pandemic groups.<br /><br />The results of the study showed a further decrease in the total number of procedures performed in the post-pandemic period, with a 27% reduction compared to the pre-pandemic period. The number of prenatal cfDNA screens, on the other hand, increased by 38% in the post-pandemic period.<br /><br />The study highlights the significant impact of the pandemic on prenatal genetic testing. The decline in diagnostic procedures poses challenges for clinician training and limits the opportunity to gain adequate experience in these procedures. The researchers suggest that future studies should examine factors such as patient acceptance of screening or testing during telemedicine consultations and the rate of undiagnosed aneuploidy in the prenatal setting.<br /><br />Overall, the findings of this study indicate a continued shift in prenatal genetic screening and diagnostic testing, with a decrease in procedures and an increase in cfDNA screening. Understanding these trends and their implications is important for healthcare providers in the field of reproductive genetics.
Asset Subtitle
Submitter Only - Miranda Blanco-Breindel, MD; Co-Author - Grace Lee, BA; Presenting Author - Sara S. Rabin-Havt; Co-Author - Susan D. Klugman, many; Co-Author - Miranda Blanco-Breindel, MD;
Meta Tag
Cell free DNA/cfDNA
Genetic Testing
Noninvasive prenatal screening (NIPS)
Prenatal Diagnosis
Co-Author
Grace Lee, BA
Co-Author
Susan D. Klugman, many
Co-Author
Miranda Blanco-Breindel, MD
Presenting Author
Sara S. Rabin-Havt
Submitter Only
Miranda Blanco-Breindel, MD
Keywords
Montefiore Medical Center
Bronx, NY
COVID-19 pandemic
prenatal genetic screening
diagnostic testing
amniocentesis
chorionic villus sampling
prenatal cell-free DNA screening
post-pandemic period
clinician training
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