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2023 ACMG Annual Clinical Genetics Meeting Digital ...
Nutritional Markers Of Histamine Intolerance in Eh ...
Nutritional Markers Of Histamine Intolerance in Ehlers-Danlos Syndromes
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A retrospective analysis of nutritional test results from 60 patients with Ehlers-Danlos syndrome (EDS) was conducted. The test assessed organic acids and amino acids and provided information about deficiencies or excesses. Elevated levels of xanthurenic acid, kynurenic acid, and essential amino acids indicated a need for vitamin B6 to address biochemical dysfunction. Glutaric acid at high levels was associated with glutaric aciduria type 1, while milder elevations indicated riboflavin deficiency. These markers also correlated with histamine intolerance. Nutritional testing can be a useful tool in understanding and treating the various manifestations and comorbidities of EDS. Patients with EDS are at risk for nutritional imbalances due to GI dysmotility and the use of medications that interfere with nutrient absorption. MCAD is a recognized comorbidity in EDS, and its complications are partly due to histamine. Histamine intolerance can be caused by a deficiency in vitamin B6 or by mast cell degranulation. The study examined nutritional markers for histamine intolerance in individuals with EDS. Results showed abnormal levels of amino acids and high values of glutaric acid, xanthurenic acid, and kynurenic acid in a significant proportion of patients, indicating B6 insufficiency and potential histamine intolerance. This is significant since many patients were already taking riboflavin-5-phosphate supplements. In conclusion, nutritional testing can provide insight into the biochemical status of patients with EDS and guide appropriate nutritional interventions. The study was funded by the Ehlers-Danlos Syndrome Research Foundation.
Asset Subtitle
Co-Author - Jessica Pizano, DCN; Co-Author - Alissa Zingman, MD MPH; Co-Author - Isabelle Brock, MD; Co-Author - Anne Maitland, MD, PhD; Co-Author - Jane R. Schubart, PhD, MBA; Presenting Author - Clair A. Francomano, MD;
Meta Tag
Gastrointestinal System
Musculoskeletal system
Co-Author
Jessica Pizano, DCN
Co-Author
Alissa Zingman, MD MPH
Co-Author
Isabelle Brock, MD
Co-Author
Anne Maitland, MD, PhD
Co-Author
Jane R. Schubart, PhD, MBA
Presenting Author
Clair A. Francomano, MD
Keywords
retrospective analysis
Ehlers-Danlos syndrome
organic acids
amino acids
vitamin B6
glutaric acid
riboflavin deficiency
histamine intolerance
nutritional imbalances
nutritional markers
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