2023 ACMG Annual Clinical Genetics Meeting Digital Edition: Poster Gallery-Genetic Determinism Beliefs Are Associated With Decreased Genetic Testing Utilization and Increased Willingness to Participate in Genetic Research

Genetic Determinism Beliefs Are Associated With Decreased Genetic Testing Utilization and Increased Willingness to Participate in Genetic Research

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The document acknowledges the data provided by the Kaiser Permanente Research Bank (KPRB) and the support from Kaiser Permanente's "Garfield Memorial Fund". The research aims to understand the association between beliefs in genetic determinism, utilization of genetic testing, concerns about genetic discrimination, and willingness to participate in genetic research.<br /><br />The study conducted an online survey among adult Kaiser Permanente (KP) members in seven regions nationwide. Eligible participants were those invited to participate in the KP Research Bank within the past 2.5 years, including both those who consented and those who did not respond to the invitation.<br /><br />The results suggest that stronger beliefs in genetic determinism are associated with lower utilization of clinical and direct-to-consumer genetic testing, as well as higher willingness to participate in genetic research. These findings may have implications for counseling patients with strong genetic determinism beliefs on the risks and benefits of genetic testing, as well as recruiting participants for genetic research studies.<br /><br />In total, 10,369 KP members completed the survey, with a response rate of 18%. The respondents were predominantly female (65%) and non-Hispanic White (44%). The majority were aged 60 or above (41%) and had a post-graduate degree (29%).<br /><br />Data analysis involved dividing responses into quartiles based on genetic determinism scores and using logistic regression to calculate adjusted odds ratios. The odds ratios were calculated for genetic testing utilization, willingness to participate in genetic research, and genetic discrimination concerns across the quartiles of genetic determinism scores.<br /><br />The document includes a table with descriptive statistics of the survey respondents, as well as a figure depicting the odds ratios of genetic testing utilization, willingness to participate in genetic research, and genetic discrimination concerns across the quartiles of genetic determinism scores for each Kaiser Permanente region.<br /><br />Overall, the study highlights the relationship between beliefs in genetic determinism and behaviors and attitudes related to genetic testing and research participation.

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Presenting Author - Jonathan L. Qu, BA; Co-Author - Andrea N. Burnett-Hartman, PhD; Co-Author - Mark Duggan, MA; Co-Author - John L. Adams, PhD;

Meta Tag

Ethical Legal and Social Issues

Genetic Testing

Co-Author Andrea N. Burnett-Hartman, PhD

Co-Author Mark Duggan, MA

Co-Author John L. Adams, PhD

Presenting Author Jonathan L. Qu, BA

Keywords

Kaiser Permanente Research Bank

Garfield Memorial Fund

genetic determinism

genetic testing

genetic discrimination

willingness to participate

online survey

KP members

data analysis

odds ratios