2023 ACMG Annual Clinical Genetics Meeting Digital Edition: Poster Gallery-Genetic Ancestry analysis using 46 AIM-InDel in three population groups of Colombia: Amerindian, African-descent and European-admix populations

Genetic Ancestry analysis using 46 AIM-InDel in three population groups of Colombia: Amerindian, African-descent and European-admix populations

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This document presents the results of a genetic ancestry analysis conducted on three population groups in Colombia: Amerindian, African-descent, and European-admix populations. The study aimed to determine the proportions of genetic ancestry within these populations and understand the dynamics of admixture.<br /><br />The results showed that the average European proportion in the European-admix Colombian population was 54.7%, with 38.2% Amerindian and 7% African descent. For the Amerindian population, the average native American proportion was 89.7%, with 7.1% European and 3.2% African. However, there were some geographic differences in ancestry proportions among Amerindian tribes.<br /><br />In the African-descent population, the average African proportion was 67.4%, while the European proportion was 19.7% and the Amerindian proportion was 12.9%. However, there was significant admixture with European ancestry ranging from 10-30%, and Amerindian admixture between 6-22% in nearby geographical areas.<br /><br />The study also highlighted the importance of considering regional differences when analyzing genetic ancestry. Admixture dynamics varied within the Chocó department, with significant admixture with European and Amerindian ancestries. It was found that a single African descent population cannot be used as an indicator of admixture, as wide differences in ancestry proportions were found in nearby geographical areas.<br /><br />These results have implications for population genetics, anthropology, forensics, and pharmacogenetics studies. The findings provide valuable insights into the genetic diversity and ancestral origins of different population groups in Colombia.<br /><br />Overall, this study contributes to our understanding of the genetic makeup and admixture patterns in Colombia, shedding light on the complexities of population history and migration.

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Co-Author - Juan J. Yunis, MD, MSc; Presenting Author - Luz K. Yunis, MD, MSc, PhD(c); Co-Author - Jair A. Perez, MD;

Meta Tag

Pharmacogenomics

Polymorphism

Population Genetics

Co-Author Juan J. Yunis, MD, MSc

Co-Author Jair A. Perez, MD

Presenting Author Luz K. Yunis, MD, MSc, PhD(c)

Keywords

genetic ancestry analysis

Colombia

population groups

Amerindian

African-descent

European-admix

proportions of genetic ancestry

admixture dynamics

regional differences

genetic diversity