2023 ACMG Annual Clinical Genetics Meeting Digital Edition: Poster Gallery-Colon cancer is uncommon in Lynch sydnrome patients having colonoscopy with chromoendoscopy

Colon cancer is uncommon in Lynch sydnrome patients having colonoscopy with chromoendoscopy

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Chromoendoscopy, a technique that involves spraying colored dyes onto the colon to highlight precancerous polyps, may be effective in preventing colon cancer in patients with Lynch syndrome, a hereditary condition associated with a high risk of the disease. This is according to a long-term study conducted by Mayo Clinic researchers. The study evaluated 56 Lynch syndrome patients who underwent 197 colonoscopies with chromoendoscopy between 2009 and 2022. None of the patients developed colon cancer, and no surgery was required for colon polyps. During 57% of the chromoendoscopies, some type of colon polyp was detected, with adenomatous polyps, which are associated with Lynch syndrome, found during 30% of the procedures. The median age of patients at their first colonoscopy was 51 years, and the median time between the first and last colonoscopy was 3 years and 6 months. The mean procedure time for chromoendoscopy was 39 minutes, compared to 18 minutes for a standard colonoscopy. Although the results are encouraging, additional time is needed to determine how chromoendoscopy compares to standard colonoscopy in terms of preventing colon cancer in Lynch syndrome patients.

Asset Subtitle

Submitter Only - Douglas L. Riegert-Johnson, MD; Presenting Author - Douglas L. Riegert-Johnson, MD;

Meta Tag

Cancer Syndromes

Gastrointestinal System

Natural History

Presenting Author Douglas L. Riegert-Johnson, MD

Submitter Only Douglas L. Riegert-Johnson, MD

Keywords

Chromoendoscopy

colored dyes

colon

precancerous polyps

colon cancer

Lynch syndrome

hereditary condition

Mayo Clinic

long-term study

colonoscopies